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Designing a Definitive Islet Sheet Study

April 2nd, 2012

Large-animal studies will demonstrate whether the Islet Sheet is ready for a clinical trial. In previous posts I have discussed the partnership doing this study: the Cedars-Sinai Diabetes and Obesity Research Institute, the islet transplantation group at UC Irvine, and our company Islet Sheet Medical. I have also laid out the study design. Today I want to describe [...]

Islet Sheet Updates
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Looking for a Ton of Islets

March 19th, 2012

The Islet Sheet is an encapsulation technology designed to work with any cell that secretes anything of therapeutic value. Hanuman Medical Foundation is funding the Islet Sheet Project  with the goal of demonstrating that we can cure people with type 1 diabetes with sheets containing primary islets — that is, islets of Langerhans isolated from [...]

Diabetes Technology
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My Favorite Pages

March 5th, 2012

Over the past six months, Hanuman Medical Foundation has consolidated three websites to create this one devoted to explaining and reporting on the Islet Sheet Project. Our company, Islet Sheet Medical, provided many of the graphics used to explain islet transplantation and the Islet Sheet. (The company no longer has its own website.)  So now [...]

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“Glucose Responsive Insulin” Will Not Improve the Lives of Type 1 Diabetics

February 19th, 2012

I spend time studying developments in diabetes research, and when possible I like to help other diabetes decision makers with my analysis. Today I am sharing a letter I sent to the president of Juvenile Diabetes Research Fund (JDRF), Jeffrey Brewer, explaining why I think their Glucose Responsive Insulin program is highly unlikely to produce [...]

Scott's Opinion

Design Protocol for Large-Animal Islet Sheet Study

January 30th, 2012

My last posting marked the start of trials at the new Cedars-Sinai lab to determine the efficacy of the Islet Sheet in large mammals—a long-awaited goal. It also talked about Professor Richard Bergman’s vision for his new Diabetes and Obesity Research Institute there. The fact that Bergman, known as a leader in type 2 research, [...]

Current Research
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The Crucial Year for Islet Sheet is 2012

January 17th, 2012

A year ago I posted an article to this blog titled “The Crucial Year for Islet Sheet is 2011.”  I was off by a year, as it turned out; last year was a transition year. The crucial year begins today. As I wrote last year, “The definitive experimental model is large animals (pig, dog, monkey) [...]

Islet Sheet Updates
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Advice for Paul of Michigan

January 2nd, 2012

Question: Hi Scott – my name is Paul B***** from Oxford, Michigan. I am a type 1 diabetic, diagnosed at age six. I am now studying Cell and Molecular Biology as an undergrad at Grand Valley State University. I was reading your work, and I’ve become fascinated with the idea of bioengineering and immunology. It’s [...]

Diatribe, Scott's Opinion
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Interview at JDCA Blog

December 23rd, 2011

The Juvenile Diabetes Cure Alliance sometimes features an interview with a type 1 diabetes researcher.  Recently they published an interview of me discussing the Islet Sheet.  Here is the text reproduced; for the original click the link. Scott King was diagnosed with type 1 diabetes in 1978.  He worked as an investment analyst specializing in [...]

Diabetes in the Press
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How Islet Autotransplantation Led to the Islet Sheet

December 12th, 2011

When I tell the story of the Islet Sheet these days, I find that I am emphasizing the importance of islet autotransplantation, or autografting. It’s success was the inspiration for the research that led to the Islet Sheet. The story in brief: The Islet Sheet is a second-generation islet encapsulation device intended to make the [...]

Type 1 Diabetes Classic
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The Year of the Dog

November 27th, 2011

Welcome to our new website!  It is a pleasure to resume this blog, now named The Sheet—for the Islet Sheet, of course. (It’s also journalism slang for a periodical.)  This is an exciting time at Islet Sheet Medical.  We have made an important addition to our team. VoxPop Films is making a documentary about our [...]

Islet Sheet Updates
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