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Archive for the ‘Scott’s Opinion’ Category

“Glucose Responsive Insulin” Will Not Improve the Lives of Type 1 Diabetics

February 19th, 2012

I spend time studying developments in diabetes research, and when possible I like to help other diabetes decision makers with my analysis. Today I am sharing a letter I sent to the president of Juvenile Diabetes Research Fund (JDRF), Jeffrey Brewer, explaining why I think their Glucose Responsive Insulin program is highly unlikely to produce [...]

Scott's Opinion

Advice for Paul of Michigan

January 2nd, 2012

Question: Hi Scott – my name is Paul B***** from Oxford, Michigan. I am a type 1 diabetic, diagnosed at age six. I am now studying Cell and Molecular Biology as an undergrad at Grand Valley State University. I was reading your work, and I’ve become fascinated with the idea of bioengineering and immunology. It’s [...]

Diatribe, Scott's Opinion
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Question from France

March 15th, 2011

Related Documents Mammalian Hibernation: Cellular and Molecular Responses to Depressed Metabolism and Low Temperature HANNAH V. CAREY, MATTHEW T. ANDREWS, AND SANDRA L. MARTIN Read the PDF I received from France: Question: Mr, quel est le rapport de l hybernation chez les animaux et le deficit de la secretion de l insuline subite ou a [...]

Scott's Opinion
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Question from a medical student

November 7th, 2010

Ireceive many questions through this web site. Most are personal, often related to a family member with diabetes, but sometimes I use the email to inspire a column (see for example Back to Basics). This week I received my first question from a medical student. Question: Hello Dr. King! As a Type-1 diabetic of over [...]

Scott's Opinion

Type 1 Diabetics are Different: Their Life Depends on Insulin

September 26th, 2010

I sometimes think those of us advocating for type 1 (juvenile) diabetics would be better off if our disease had a different name.

The vast majority of diabetics are type 2 diabetics. Genetic and metabolic studies have revealed that type 2 diabetes is a large group of diseases that range from seemingly healthy people with high glucose after meals to people with declining insulin secretion that require insulin. Type 2 diabetes has a strong inherited component, with identical twin concordance of 90%. Most type 2 diabetics are never diagnosed, going through life unaware of their diabetes. Many can control their diabetes with diet and exercise alone. Many take pills of various sorts and some require insulin.

Scott's Opinion

Islet Sheet 101: The basics

July 18th, 2010

Question: I was wondering if you can explain your project in layman’s terms. I don’t understand what islets are; I do get that the sheets will hold something to help with blood sugars, but will that be human- or pig-based? What type of freedom will diabetics have? Will they be able to eat whatever they want, or not worry about lows? Will there be side effects? What makes your ideas better than other companies experimenting with islets? How will it work? What about the hormone Amylin: will that be present? Sorry for the stupid questions.

Scott's Opinion

Questions from a reader

June 7th, 2010

One of the pleasures of writing for is I get feedback on the thoughts of a group of interested diabetics in the world.  It lets me know what is less than clear on our web sites.  I recently received the following questions from MK.

Scott's Opinion

The Cure is Five Years Away (and always will be)

May 23rd, 2010

Newsweek Magazine states on its cover: “Desperately Seeking Cures: Medical research isn’t making progress rapidly enough.” Their key observation is that the academic medical research world is structured with incentives that perversely favor glamourous discoveries, not cures. The article does not cover diabetes research. I decided that today I would apply it to my area of interest, juvenile diabetes. So this is today’s question: Why is there no cure for type 1 diabetes?

Scott's Opinion

Smart Insulin: As Smart as Islets?

April 28th, 2010

Recently Elizabeth Snouffer published an interview with me at Diabetes24-7. During the discussion after, Elizabeth noted that a number of people liked the Smart Insulin approach, and she asked me to talk about how it compared with the Islet Sheet. Today I feel I was not completely fair to Smart Insulin and wanted to write a bit more.
The idea is attractive: formulate insulin so that the rate of insulin release increases as glucose goes up.
Insulin stores islets in the form of crystals, which contain both the protein insulin and the ion zinc (yes, the same zinc found in mineral supplements that is …..

Scott's Opinion

Dogs, Pigs and Diabetes

April 12th, 2010

Medicine learned of type 1 diabetes early with the observation of people who seemed to eat food and make honey out of it (diabetes mellitus means “honey passing through”). It was induced in animals for the first time in 1889 when Oskar Minkowski surgically removed the pancreas of a dog. Thus did the dance of knowledge of diabetes in humans and animals begin.

Scott's Opinion