the sheet blog

Archive for the ‘Type 1 Diabetes Classic’ Category

How Islet Autotransplantation Led to the Islet Sheet

December 12th, 2011

When I tell the story of the Islet Sheet these days, I find that I am emphasizing the importance of islet autotransplantation, or autografting. It’s success was the inspiration for the research that led to the Islet Sheet. The story in brief: The Islet Sheet is a second-generation islet encapsulation device intended to make the [...]

Type 1 Diabetes Classic
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The 30th Anniversary of "Prospects in Diabetes Therapy"

October 3rd, 2010

Thirty Years ago a Wall Street Investment Banking firm published a research report on the future of the diabetes industry. It was the first time a Wall Street firm had ever considered diabetes as an investment opportunity. The author was a 25-year old who had had type 1 diabetes for two years. That was me.

Type 1 Diabetes Classic

DCCT Study

December 7th, 2009

“As you know I think tight control is a good idea. The clinical study that is going to prove that tight control prevents vascular disease is about halfway done and is looking promising. So let’s stick with your tight control. I don’t want your kidneys to fail.” This was the first I heard of the DCCT study, from Dr. Andrew Drexler, when I lived in New York City and was his patient.

Type 1 Diabetes Classic
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The Discovery of Insulin

June 25th, 2009

In a previous essay I wrote about the Edmonton Protocol paper as a diabetes classic. I realized that the second classic I needed to discuss had to be Banting & Best’s discovery of insulin. I had never read it. Then I discovered how hard it was to get.

Type 1 Diabetes Classic

The Edmonton Protocol

May 13th, 2009

Diabetes cured! screamed the press. Few type 1 diabetics can forget the excitement that greeted the Edmonton Protocol’s publication and the surge of hope it engendered in 2000. Although the authors of the paper did little to encourage the hyperbole, it was hailed as a cure. It is not, but it is perhaps the most important milestone to date in the development of islet transplantation.

Type 1 Diabetes Classic