Paul de Vos in his laboratory.

University Medical Center Groningen, Netherlands

The work of Paul de Vos on issues related to islet transplantation is recognized as some of the most advanced in Europe. Professor de Vos is based in the Department of Pathology and Medical Biology, Section of Immunoendocrinology, at the University Medical Center Groningen. He heads an EU-funded consortium working to define the requirements for encapsulation of biological material. (See Biomaterials article.)

Founded in 1614, the University of Groningen is the second-oldest university in the Netherlands. It enjoys an international reputation as one of the leading research universities in Europe.

The Immunoendocrinology Section is known for its fundamental and applied research on the areas where immunology and endocrinology meet. Recent research has shown that the immunological activity of an organism is under tight control of the endocrine, metabolic activity. This can be observed, notably, during the female reproductive cycle and pregnancy, after organ transplantation, and in mucosal disorders (Crohn’s disease, colitus). The section’s research focuses on the etiology and pathophysiology of (dys)regulation of the immune system in such circumstances.

Professor de Vos’s group has access to many state-of-the-art imaging modalities. Currently they are studying tissue samples from the rodent Islet Sheet studies at UC Irvine, with the goal of identifying the nature of cellular reaction to Islet Sheet Medical’s alginate and Islet Sheets.

Paul de Vos, PhD

Dr. Paul de Vos is associate professor of immunoendocrinology in the Department of Pathology and Medical Biology, Section of Immunoendocrinology, University Medical Center Groningen. His areas of research have been microencapsulation of islets, alginate, epithelial cells, immuno-modulation, and targeting of cells and food components.

He has consulted with private companies, including Novo Nordisk, on projects concerning islet cell physiology, stem cells and immune isolation, and food and immunology. He is the author of many published papers on these subjects.