June 14, 2013
This spring, Dr. Jonathan R. T. Lakey, a principal collaborator in the Islet Sheet Project, was awarded a major grant by JDRF (formerly the Juvenile Diabetes Research Foundation) to study encapsulated islet transplantation over the next three years. Dr. Lakey is Associate Professor of Surgery and Biomedical Engineering and Director of Research and Clinical Islet Program at the University of California, Irvine, where he leads a group that is renowned for its work on isolating and transplanting islets for the treatment of type 1 diabetes. The grant will provide funding up to approximately $1.27 million over the three years.
Research covered by the grant will include further investigation of the Islet Sheet, a proprietary technology of Islet Sheet Medical, San Francisco. About his collaboration with the Islet Sheet Project, Lakey says, “Perhaps the greatest need in the field of islet transplantation is to make the metabolic benefits available to patients with type 1 diabetes, without the need for chronic immunosuppression. My long commitment to working with the Islet Sheet technology speaks to my belief in its promise for realizing that goal. And this welcome support from JDRF should speed our progress.”
April 15, 2013
Over the weekend, Hanuman Medical Foundation received a very generous matching grant of $50,000 to encourage community-based funding for the Islet Sheet Project. This means Hanuman will begin an aggressive social media and grassroots campaign to raise $50,000 to bring a total of $100,000 to the Islet Sheet Project. HMF is very grateful for this generous award and hopes it will inspire others in the Type 1 community to donate to this promising line of research for a cure to juvenile diabetes.
October 19, 2012
First Real-Time Images and Data Presented at Transplantation Congress
August 20, 2012
At the recent 24th International Congress of the Transplantation Society in Berlin, researchers presented evidence that the implanted Islet Sheet helps oxygen-bearing blood vessels around the sheet to proliferate. This addresses one of the main problems with encapsulated islets: making enough oxygen available for the islets to thrive and deliver insulin as needed to the body of a person with diabetes. (Get PDF of presentation.)
July 16, 2012
A July 10 story in The Oregonian describes work being conducted by researchers at Oregon Health & Science University on using lactose to stabilize the hormone glucagon for use by type 1 diabetics in a computer-controlled pump. For people who inject insulin (or use an insulin pump) and sometimes miscalculate the dose, glucagon can counteract the low blood sugar condition that follows. Current methods of administering glucagon to manage low blood sugar are cumbersome and the material spoils quickly; the researchers hope that adding lactose will enable glucagon to be dispensed more conveniently by pump, monitored by a smartphone app. The ultimate goal of all such projects is a “closed-loop” system with built-in monitoring of insulin and blood sugar levels—a true artificial pancreas. Islet Sheet Medical founder Scott King, asked to comment on the challenges of this research, noted that the computer algorithm for such a system “must be good enough to trust one’s life to it.” So far that goal is still in the future. Read the article online or download a PDF.
June 1, 2012
Last month, the Woodbury Foundation generously awarded the Hanuman Medical Foundation a $37,000 grant to support HMF's continuing support for research that improves life for people with type 1 diabetes. Type 1 diabetes affects nearly 8 million people world-wide, and, different from type 2 diabetes, most type 1 diabetics are diagnosed early on in life. Hanuman Medical Foundation is pleased to accept this award as it continues to support research throughout the world in search for a cure for type 1 diabetes.
March 9, 2012
Hanuman Medical Foundation recently interviewed Dr. Richard N. Bergman, PhD, about the new Cedars-Sinai Diabetes and Obesity Research Institute he directs, and about his distinguished career as a diabetes researcher—in particular his work with the Islet Sheet Project. Read the Q&A (PDF download).
January 17, 2012
Today the definitive large-animal study of the Islet Sheet encapsulation device kicked off with the first surgical procedure under the approved protocol. This was a practice pancreatectomy on a canine recipient, followed by islet isolation. The islets will be used to test Islet Sheet fabrication and in further experiments. The trial is being jointly conducted at the new Cedars-Sinai Diabetes and Obesity Research Institute, directed by Richard N. Bergman, PhD, with Marilyn Ader, PhD, (principal investigator on the Islet Sheet Project) as associate director, and at the islet research...
December 20, 2011
The Juvenile Diabetes Cure Alliance (JDCA) blog has published an interview with Scott R. King, president of Islet Sheet Medical and co-inventor of the Islet Sheet therapy for type 1 diabetes. JDCA is a coalition formed to unite donors in pressing for a “practical cure” for type 1 by the year 2025. Hanuman Medical Foundation, which supports the Islet Sheet research, has been in discussions with JDCA about goals and approaches the two organizations share.
November 10, 2011
Vox Pop Films of Los Angeles is shooting a documentary film called Patient 13, about Islet Sheet Medical founder Scott King and his quest to conquer type 1 diabetes with thin-sheet encapsulation technology. The film will be released in 2012. Learn about Vox Pop Films; view a video of Scott and his work
October 26, 2011
After extensive review, Cedars-Sinai Medical Center formally approved the Islet Sheet Project’s research protocol for large-animal efficacy studies. Supported by Hanuman Medical Foundation, the studies will be led by Principal Investigator Marilyn Ader, collaborating with researchers at the University of California, Irvine, and Islet Sheet Medical Company of San Francisco.