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Islet Sheet Team Presents First Large-Animal Data

October 19, 2012

On October 2, at the 48th annual meeting of the EASD (European Association for the Study of Diabetes) in Berlin, the Islet Sheet Project team presented the first set of data from its current study of the Islet Sheet in diabetic pigs. Professor Jonathan Lakey of the University of California, Irvine, principal investigator for the study, presented the data in the form of a detailed poster, which was received with much interest.

This gathering of the EASD is comparable to the annual meeting of the American Diabetes Association (ADA). Attendance figures for 2012 were not yet available; in 2011 there were 17,462 attendees from 127 countries. They are people interested primarily in developments in clinical diabetes but also in learning about the latest research for their own edification and for the education of their diabetic patients.

Such large-animal studies are a crucial step before clinical trials of the Islet Sheet. “The pig is a good model in many ways, as its metabolism and insulin requirements are similar to those of humans,” says Scott King, founder of Islet Sheet Medical. “They can be challenging to study, as other teams have found, but we have already learned much from the early weeks of working with them.”

The presentation concludes: “We have established a diabetic porcine model that can be successfully used for in vivo testing of the Islet Sheets in their ability to reverse type 1 diabetes.”

Research personnel are from Prof. Lakey’s lab at UC Irvine and from Islet Sheet Medical Company of San Francisco. The study is funded by Hanuman Medical Foundation and the Department of Surgery, University of California, Irvine.