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Hi Scott, how do your team members view about betatrophin and 2H10 cure since so many of different professors are speaking of different things for type 1 amd type 2 diabetes, it is confusing my science freak mind. I still believe as for type 1 diabete, your team of professor are the most genius and ethical amount the medical world and your team are welcome to take my comment to which ever organization your team member need that would benefit to get more funding and quicker approval since there is not one diabete family member interested to see scientific community finding solution that would only happen in another few hundred years ideology instead, all of those family member wished to have workable solution that allow them to live in virtually normal life and live as long as normal person would. Those family members certainly have no fantasy of perfect perfect solution would come out just the next day. It's better to have realistic fix first than work on more perfected solutions in the long run. Professor Scott, your team member are deeply respected by me because your team are ethically understanding the need to bring practical solution to society in the short term instead of waiting for indefinitely for only the ultimate perfect solution that may be still too far out of reach still. I want FDA, NIH, ADA, Cedar Sinai, and all of associated organizations to know how real diabete family and family member feel about this and begging them to corporate with your team member very closely and not to elevate unrealistically high standard since the medical world do not have better solutions to replace your teams work at all. By asking for the rediculous expectaction will only harm type 1 diabete family instead of benefit from it. Professor Scott, my wife side distant relative is on insulin for many years, my wife is gestational diabete while preganent, my friends father die from diabete in the year 2009, and my male friend is gestational diabete and taking metformin for the last three month now. With so many friend and relatives in my circle with diabete, I feel all organization should listen to my voice and take serious consideration even if I do not have the right to overide other organizations professor decisions. I just want other professors and government organization to hear how true diabetic family feels and needs instead of living in there own world. It seems to me that other organizations have work in this things for too long and forgeting the crying voice of diabetic family otherwise they would not have increasing the expectation to the level to delay the cure your team is doing for the type 1 world. It may not be okay for professor to say this things to them but how about sending them my message to them whom have plenty of diabetic family members and friends. And I want them to know keep getting hardship to your team to bring solution to diabetic world majority of diabetic world will consider your team the hero and other who delay them as the criminal. This is how diabetic family feel and it will be always be that way. Lastly, I ask other professor and government organization who is delaying them, what are they really working for, serving the entire humanity for better quality of live or promoting more death as we speak due to ideology? Professor Scott, I am not writting this to express your team not doing a good job instead, I want to write something that allows your team to bring to government organizations and other associated organizations whom are against it as wake up letter and make them think twice of what real world are up to instead of living in there own fantasy medical lab.
Derrick, 2H10 is a new concept, and I am cautious because the target is the vasculature system. Avastin, a related concept for cancer, has proven a disappointment compared to its early promise. I won't get too excited until there are more data. Actually,... READ MORE
Type 1 diabetes (T1D) affects 1 in 10 of the 141 million people with diabetes worldwide. In this form of diabetes, the body’s immune system—for reasons still unknown—mistakenly targets specialized clusters of cells in the pancreas called the islets of Langerhans. Specifically, this immune malfunction destroys beta cells, which produce the hormone insulin—an essential factor in how we metabolize nutrients.
Without insulin to make glucose available to cells for fuel, glucose builds up in the blood, causing dangerous short-term symptoms and long-term damage to the vascular system.
Sooner or later, the disease shuts down insulin production completely. Well before then, though, people diagnosed with type 1 come to depend on injected insulin to control their blood sugar level. With today’s insulin therapies and a closely monitored diet plus exercise, a determined individual can control his or her blood sugar well enough to avoid most vascular decay. But the cost is high—financially and in freedom of lifestyle. The current options are a poor substitute for fully functioning islets.
Spending on diabetes research and treatment is soaring. According to the American Diabetes Association, the total costs of diagnosed diabetes amounted to $174 billion in 2007. The National Institutes of Health (NIH) alone budgeted $150 million for type 1 research in 2010; millions more came from private foundations. But because the disease is so complex and we don’t yet understand what triggers the autoimmune attack, a true cure remains frustratingly out of reach, even while methods of managing T1D gradually continue to improve.
Researchers are focusing on four main approaches:
- Developing drugs to control the immune malfunction that attacks islets and beta cells
- Developing drugs that can regenerate beta cells or keep them alive and functioning
- The “closed-loop” artificial pancreas, a system that automates insulin delivery through the skin via a pump attached to the body
- Transplanting healthy islets (obtained from various sources) into the body so that this “bioartificial pancreas” can produce insulin on its own
All of these approaches have potential, and all have major obstacles to reaching the goal of safely and effectively treating large numbers of people with type 1. For compelling reasons we’ll set forth, Hanuman Medical Foundation is committed to the last approach: developing a true bioartificial pancreas.
- Type 1 diabetes is a debilitating, potentially fatal, autoimmune disease.
- Massive research efforts take several promising approaches, but a cure is still in the future.
- Hanuman Medical Foundation strongly supports research on islet implantation and the bioartificial pancreas.